PhenQ vs Phentermine: What’s Best For Weight Loss?

January 10, 2024 |

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Have you been struggling to achieve your desired weight loss results even after stepping on your cravings and dragging yourself to the gym every day, and now are looking for the BEST weight loss pills to help you with it?

Well, I must say, you have short-listed the right options!

PhenQ and Phentermine have worked great for many, but they differ SIGNIFICANTLY in their working mechanisms.

While PhenQ uses all-natural vegan ingredients to induce fat loss in 5 different ways, Phentermine is a strong psychostimulant that messes with your brain to curb hunger.

Ready to find out which one yields better results without deadly side effects? Here’s a quick sneak-peak into my findings:


Overall rating: 4.9/5
  • Over-the-counter pill
  • Two pills per day
  • Eliminates fat and prevents its re-accretion
  • Curbs hunger and gives energy
  • Boosts metabolism & increases thermogenesis
  • All-natural formulation – safe for long-term use


Overall rating: 2.8/5
  • Prescription-only drug
  • Dosage varies per person
  • Induces fat loss by curbing hunger only
  • Not effective in preventing fat re-accumulation
  • Does not boost metabolism or increase thermogenesis
  • Not safe for long-term use

What Is Phentermine And How It Works?

‘Phentermine’ is a sympathomimetic amine, a stimulant compound that mimics certain neurotransmitters and tweaks the brain signaling to suppress your appetite, energize you, and put you in a happy mood.

It has held the status of being an FDA-approved weight loss supplement since 1959. However, it is suspected of having addiction potential. This imposes certain restrictions on it and limits it for use in certain groups. For this reason, its purchase is prescription-controlled.

Your doctor may prescribe phentermine to support your weight loss progress if you have a BMI of 30 kg/m2 or greater.

You may also be eligible for this treatment if your BMI is greater than 27 kg/m2 and you suffer from some underlying illnesses.

Find out how much weight you can lose with Phentermine here.

However, obesity treatment with Phentermine can only be pursued short-term, typically for a duration that lasts up to 12 weeks.

You wonder why is that? Because of its DEADLY side effects!

Additionally, Phentermine may give a false positive result for amphetamine. The highest chance for it to happen is when the 5-panel drug screening is performed within 5 to 7 days of phentermine intake.

Phentermine Pros

  • Suppresses appetite & burns fat
  • Science-backed efficacy
  • FDA-approved weight loss aid
  • Supports rapid weight loss

Phentermine Cons

  • Included in category X by the FDA, hence, unsafe in pregnancy
  • Gets transferred into breast milk and reduces the milk supply
  • Potential for abuse
  • Contraindicated with alcohol, other diet pills, and certain medicines
  • Risks are amplified in certain illnesses, such as underlying kidney problems
  • Should be prescribed with precaution to the elderly
  • Might give a false-positive drug test
  • Available only on prescription
  • Not safe for long-term use

To buy Phentermine online, you would need to submit your doctor’s prescription first. So, no link here, sorry. 🙁

What is PhenQ & How Does it Work?

PhenQ is an over-the-counter supplement that works well and is accessible to all overweight and obese individuals. 

It uses multiple proprietary blends like a-Lacys Reset, innoslim, caffeine, and capsimax powder. Other ingredients that impart a significant weight loss impact are the nopal fiber and L-carnitine fumarate.

The multi-faceted action of this ingredient combination helps:

>> Cuts fat,

>> Blocks fat accumulation,

>> Curbs appetite,

>> And keeps you energized.

The best part is that you can take PhenQ for as long as you wish. Moreover, PhenQ won’t set off a drug test.

PhenQ Pros

  • Promotes weight and fat loss
  • Safe with mild side effects
  • Suitable for long-term use
  • Efficacy is critically acclaimed by over 190,00 users worldwide
  • Produced in FDA and GMP-approved facilities
  • 60-day money-back guarantee
  • Free US delivery

PhenQ Cons

  • Might bother caffeine-sensitive individuals (150 mg caffeine)
  • Not for ages less than 18 years
  • Not suitable for pregnant or nursing women
  • People with underlying illnesses should use with doctor’s advice

PhenQ Vs. Phentermine – Product Comparison

PhenQ total users

Key Ingredients

PhenQ is a multi-ingredient fat burner and weight loss supplement, whereas phentermine uses a single active compound, ‘phentermine HCl’ to bring about its effect.

PhenQ uses different proprietary blends like capsimax and InnoSlim to accelerate the fat breakdown in the body and prevent its re-accumulation, respectively. Likewise, it employs nopal fiber and caffeine to promote fullness by slowing gut motility and delaying gastric emptying. 

In comparison, phentermine HCl has a stimulant effect, and it increases fat burning, promotes appetite suppression, and increases energy levels all by activating the fight-or-flight response in our body.

Some studies also found that phentermine therapy leads to improvements in waist circumference.

Common Ingredients

  • None

PhenQ Unique Ingredients

  • Caffeine Anhydrous
  • L-carnitine L-tartrate
  • α-LACY’s reset
  • Nopal
  • B-vitamins (B3, B6, B12)
  • Chromium picolinate
  • InnoSlim
  • Capsimax
  • Piperine

Phentermine Unique Ingredients

  • Phentermine HCl

Dosage Regimen

PhenQ has a pre-defined dosage regimen, which is the same for everyone, but phentermine’s dosage is determined solely by a doctor and varies according to each person’s specific needs.

Regarding PhenQ, manufacturers recommend taking it two times a day, once with breakfast and the other dose with lunch, but not later than 3 pm.

Comparatively, on interaction with some phentermine users, I found that the following 4 dosage patterns are most commonly followed:

–> Some individuals might find sufficient relief with a 4 mg dosage (equivalent to one-half tablet) taken thrice daily.

–> For others, taking the 15 and 30 mg capsules 2 hours after breakfast might be more suitable.

–> Alternatively, some patients may only need an 18.75 mg (equivalent to one-half tablet) dose once daily or 9.35 mg taken orally twice a day.

–> Or, some may have to take the 37.5 mg capsules or tablets (Adipex-P) 1 to 2 hours after breakfast to induce sufficient effect.


PhenQ uses multiple ingredients to impart its effect, whereas phentermine is a single active compound that brings about its many weight loss benefits.

Moreover, PhenQ has a simpler and more straightforward dosage regimen, whereas phentermine’s dosage is modifiable concerning every individual’s condition and tolerance.

PhenQ CT

Phentermine Vs. PhenQ – What Is Best For Weight Loss?

Phentermine works purely on Psychostimulation

According to different studies, phentermine may help you get rid of 3 – 5% of your initial body weight after 3 months. After six months, it may go further down by 5–7%. 

The reason is that phentermine triggers the release of norepinephrine, which signals certain sympathetic nervous system responses, and some responses of a hyperalert system, such as thermogenesis, might help burn more calories. 

Correspondingly a meta-analysis of 6 studies, phentermine monotherapy induced a mean total weight loss of 6.3 kg in 2 to 24 WEEKS!

PhenQ Eliminates Excess Fat With Natural Blends

  • a-Lacys Reset- Induces Reduction In Fat Mass

It is a combination of ALA (Alpha Lipoic Acid) and Cysteine that was launched in 2013. 

According to a clinical trial, the a-Lacys Reset led to a 7.24% reduction in body fat and a 3.44% reduction in body weight of the subjects.

PhenQ Results - Graph
  • Capsimax Powder – Melts Away The Fat

The capsimax powder contains the ‘capsaicinoids’ of capsicum, and other red peppers encapsulated in beads. These compounds may increase the metabolism rate by roughly 8%. Moreover, this beading technique ensures the regulated release of these hot compounds, which induces optimum weight loss and minimizes the risk of stomach irritation. 

Correspondingly, the results of multiple clinical trials suggest that capsimax powder prevents weight and fat gain, triggers an energy surge, and has better tolerability.

  • Nopal – Enhances Fat Excretion

Nopal is a high-fiber vegetable whose anti-obesity role can be attributed to its potential to modify the gut microbiota, which regulates obesity.

Clinical trials show that the nopal prevents weight gain and increases the fat excretion in the stool of the intervention group by as much as 11% compared to the placebo.

  • L-Carnitine – Promotes Fat Utilization As Substrate For Energy Production

L-carnitine is a naturally occurring amino-acid derivative that helps to replenish the carnitine levels in your body, which are essential in energy production from fats.

An analysis of 43 Randomized Control Trials revealed that L-carnitine supplementation has a considerable advantage of inducing weight loss and reducing Body Mass Index in overweight and obese individuals.

  • Caffeine – Cuts Away Fat Bulges 

Caffeine is a staple ingredient in many diet supplements because it enhances thermogenesis and metabolism rate.

A meta-analysis of 13 Randomized Control trials confirmed that for every two-fold increase in caffeine intake, there is also a two-times mean reduction in weight, BMI, and fat mass.

  • (EXCLUSIVE) InnoSlim – Maintains Fat Loss

Unlike phentermine, PhenQ will help you retain your fat loss progress with a proprietary blend ‘InnoSlim.’

InnoSlim activates an adiponectin and AMPK signaling pathway, which regulate fat breakdown and glucose uptake, hence lowering the level of fat and sugar in the bloodstream and preventing them from depositing as fat stores.

Both Avert Pesky Cravings

PhenQ has capsimax powder, which contains capsaicinoids that can restrict hunger. This is evident from a clinical trial in which participants who took it before meals had a reduction in their ad libitum (Desired) energy intake by 309.9 kJ (74.0 kcal).

Besides this, the caffeine in PhenQ and phentermine use a similar mechanism to control your eating behavior.

Both increase the level of norepinephrine neurotransmitter in the brain which activates receptors that promote appetite suppression. Studies on phentermine have especially noted a reduction in participants’ sugar and fat cravings.

Only PhenQ Helps You Sculpt A leaner & Muscular Body

PhenQ has the exclusive benefit of preventing the loss of lean muscles during fat loss.

PhenQ contains L-carnitine, which is proven by studies to attenuate muscle damage and soreness, hence preventing the loss of lean muscle mass.

Additionally, it contains a-Lacys reset, whose distinctive benefit is that it promotes fat loss while simultaneously encouraging muscle growth.

A clinical trial observed that it caused a 3.80% increase in muscle mass in the intervention group compared to the placebo.


Both supplements cause fat loss and help correct eating habits, but phenQ takes a multi-pronged approach, hence is more effective in the long run, whereas phentermine only has a single mechanism, and is efficacious only for the time being.

PhenQ CT

PhenQ Vs. Phentermine Side Effects – Which is Safer?

PhenQ’s Side effects

PhenQ’s ingredients may cause mild side effects such as gastrointestinal Problems bloating, constipation, diarrhea, and headache.

  • Gastrointestinal Unrest

Your gut may take some time to adjust to PhenQ ingredients. Hence, you can expect stomach discomfort, bloating, constipation, diarrhea, and related symptoms that may go away over time.

For instance, your stomach might react to nopal if you are not used to taking laxatives. Other ingredients like capsimax powder and chromium picolinate may also irritate your stomach.

  • Sleep Disturbances

The caffeine in PhenQ may disrupt sleep due to its stimulant effect and ability to increase the metabolism rate and thermogenesis. Hence, manufacturers advise that consumers should avoid it around bedtime.

In fact, our metabolism rate decreases by 15% when we sleep and research reveals that a higher metabolism rate during sleep reduces its restorative effect.

Also, the same research reported that taking caffeine before sleep delays the onset of restful sleep (stage 4 sleep (REM)) 

  • PhenQ headacheA common issue

Consumers also sometimes report an incidence of a mild headache after taking PhenQ. The caffeine content or the blood glucose-lowering effect of PhenQ might be blamed for causing this symptom.

Regarding this side effect, caffeine-sensitive people are more prone to developing headaches that are accompanied by restlessness, jitters, and other symptoms of caffeination.

On the other hand, ingredients like nopal cactus, L-carnitine, and chromium picolinate can potentially lower blood glucose.

On top of it, appetite suppression might make it drop to dangerous levels, which may increase your risk of developing headaches. You might also get symptoms like fatigue, dizziness, blurred vision, etc.

So, ensure having nutritionally complete meals every day to prevent headaches that occur because of low sugar.

Phentermine’s Side Effects

Phentermine poses the risk of both mild and life-threatening side effects that may include gastrointestinal side effects, allergy, or gut issues.

  • Allergic Reaction

Hypersensitive individuals may get triggered by certain drugs and sympathomimetic mines like phentermine.

An allergic reaction to phentermine may manifest as symptoms like:

>> Rash, itchiness, hives, swelling of the face, lips, throat, or tongue, or it may cause difficulty breathing.

Plus, it may also cause an increase in the risk of severe side effects like cardiovascular disorders. For instance, an increase in heart rate and blood pressure may cause adverse effects like primary pulmonary hypertension, irregular heartbeat, chest pain, cardiac valvular disease, or even heart attack.

  • Gastrointestinal Side effects

Sometimes, the appetite suppression by phentermine may result in uncomfortable gastrointestinal problems. Around 10% of the users report nausea or vomiting with Phentermine, which may be caused by the activation of the fight and flight response.

Users also complain of stomach pain, bloating, or gas which might occur because of an empty stomach in case the appetite suppression was too powerful.

Since the stress response of the body inhibits digestion, this could also upset your stomach. Thus, it may cause,

>> Diarrhea

>> Constipation

>> Acid reflux

>> Unpleasant taste

>> Dry mouth

>> Trouble urinating

  • Psychological changes

Phentermine alters the concentration of neurotransmitters in the brain and stimulates the sympathetic nervous system, all of which may trigger psychological disorders.

There are multiple case reports of users becoming suicidal, getting hallucinations, and developing disorders such as anxiety, depression, and psychosis.

Phentermine may even cause changes in libido in some cases.

  • Generalized side effects

You may also look forward to some generalized side effects like insomnia, headache, dizziness, blurred eyesight, or overstimulation.

So, don’t forget to make your doctor aware of your medical history. Tell them if you have any cardiovascular diseases like uncontrolled blood pressure or stroke. Also, let them know about certain conditions, such as overactive thyroid or glaucoma.

Evidence From User Review

A person replied to this Reddit post that taking phentermine caused them serious dizziness, lightheadedness, loss of vision, stomach aches, depression, fatigue, extreme appetite suppression, and fainting.

phentermine review

Who doesn’t want a risk-free weight loss? But artificially produced supplements always come with some warnings. Correspondingly, the all-natural PhenQ presents the least health risks, while Phentermine poses severe risks to heart health and may also alter mental state.

PhenQ CT

PhenQ or Phentermine – Which One is More Affordable?

PhenQ – Where To Buy & Price

PhenQ is an over-the-counter weight loss supplement that you can purchase from their official website. One bottle of PhenQ contains 60 tablets and will last for 30 days. It comes at a retail price of $79.99.

You may save the cost of one PhenQ bottle by buying a bundle of three for just $239.99 (retail price). Or you can purchase a five-bottle package for just $399.99 and save the cost of two PhenQ bottles.

Phentermine – Where To Buy & Price

Contrary to PhenQ, phentermine is a generic medication and a Schedule IV controlled substance. Therefore, in the US, it is illegal to buy it online.

You may buy authentic phentermine formulations only from pharmacies or drug stores because online deliveries may carry fake pills.

However, because of this reason, the phentermine prices vary by location, brand, form, dosage, and even at different pharmacies.

According to Good Rx, 30 tablets of 37.5 mg phentermine (highest dose) come at an average retail price of $37.21.


Phentermine comes out to be cheaper than PhenQ if compared based on the current price of their one-month supply, which is $69.99.

In contrast, the average retail price of the 37.5 mg Phentermine tablets is $37 approx.

PhenQ CT


Can I take phentermine and PhenQ together?

No, it is better to avoid taking phentermine and PhenQ together because both of them stimulate the sympathetic nervous system, so they may create a pronounced risk of causing psychological and gastrointestinal side effects like anxiety, insomnia, nausea, vomiting, etc. Besides, there is a clear warning not to pair phentermine with other weight loss supplements.

Does PhenQ contain phentermine?

No, PhenQ’s formulation is based on natural ingredients only, and it does not contain phentermine. Nonetheless, it contains caffeine to induce stimulation of the central nervous system.

Is PhenQ the same as phentermine?

No, PhenQ is an over-the-counter natural alternative to phentermine. Compared to phentermine, PhenQ poses less life-threatening health risks and can be used by the general obese and overweight population.

What Do We Recommend?

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