Can You Take PhenQ With Wellbutrin? (Warning!)

January 10, 2024 |

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Did you know that taking Wellbutrin may lead to weight fluctuations? However, there is a greater chance that it will cause weight loss instead of weight gain.

For instance, in one study, Wellbutrin led to a weight loss of 5 pounds in over 23% of the participants, while approximately 11% of them experienced weight gain.

Since there is a connection between Wellbutrin with weight changes, you can also suspect it to interfere with the PhenQ’s action.

Here is a quick glimpse into what might happen when these two drugs are combined.

Key Points:

  • Taking PhenQ and Wellbutrin together may lead to overstimulation of the central nervous system.
  • The combination may also raise blood pressure & cause dopamine toxicity. DO NOT TRY IT!
  • Find more about PhenQ on their official website here for the BEST price.

Simply put, PhenQ and Wellbutrin have similar outcomes, and the convergence of their identical potentials may cause repercussions.

But then, are all weight loss pills incompatible with Wellbutrin? If that is the case, how can you pursue assisted weight loss with Wellbutrin?

Find answers to questions like these by sticking to this read until the very end.

What Happens If You Take Wellbutrin And PhenQ Together?

There are two reasons why PhenQ is contraindicated with Wellbutrin (Bupropion).

One is that both have a similar mechanism of action, and the other is that PhenQ contains caffeine.

So, both these drugs stimulate the central nervous system in a similar way.

Consequently, if you simultaneously use them together, you may unintentionally end up overdosing on them, which can result in drastic consequences. (Read about them in detail in my detailed blog post on PhenQ and antidepressants here.)

And this doesn’t apply to Wellbutrin only; you should be careful about taking ANY antidepressants with PhenQ because most of them mess with the brain’s neurotransmitters.

For now, here is what may happen when the PhenQ-Wellbutrin combo overwhelms your physiological equilibrium:

Taking PhenQ with Wellbutrin May Increase Symptoms Of An Overstimulated Central Nervous System

It is strictly indicated in the note for consumers and professionals on the that while taking Wellbutrin, you should monitor and reduce your daily caffeine intake from all sources, including weight loss pills.

Now caffeine is the major active ingredient in PhenQ, so the Wellbutrin drug facts imply that it should also be avoided.

The reason is clear, both Bupropion and caffeine increase the nor-epinephrine (these are the names of neurotransmitters) levels in the brain and excite the neurons. Therefore, taking them together may intensify the effects of a stimulated nervous system and wreak havoc on the brain and body systems.

Note that the potential side effects listed in the Bupropion fact sheet are irregular heartbeat, nervousness, irritability, and difficulty with sleep.

Similarly, the caffeine in PhenQ is blamed for posing the risk of difficulty falling asleep, triggering anxiety, disturbed heart rate, and restlessness in sensitive individuals.

These similar side effects are clearly the reason why taking PhenQ and Wellbutrin together is not a good idea.

PhenQ cta1

Taking PhenQ with Wellbutrin May Cause Dopamine Toxicity

According to the drug interactions on, you should practice caution while taking Wellbutrin with medicines that raise dopamine levels in the brain.

The reason is that Bupropion alleviates depression by inhibiting the reuptake of dopamine (feel-good hormone) in the brain, which allows it to stay there for longer.

Therefore, if you take something additional, like the caffeine in PhenQ, to trigger dopamine release, the levels may explode. This potential of caffeine to modulate dopamine levels is backed by scientific evidence.

For instance, in one study, researchers observed that the administration of 300 mg of caffeine to 20 participants significantly increased the dopamine levels in their brains.

Now, high dopamine levels can be toxic for the central nervous system and lead to various symptoms, including restlessness, tremors, dizziness (including vertigo), agitation, poor coordination, and seizures.

Here, vertigo indicates a feeling that you are spinning despite being still.

Taking PhenQ with Wellbutrin May Elevate Blood Pressure

It is mentioned on the drug information on that taking caffeine with Wellbutrin may have additive effects and cause the blood pressure to shoot up.

The reason behind this is that the noradrenaline and dopamine released by caffeine and Bupropion can raise blood pressure through different mechanisms.

On the one hand, noradrenaline triggers a fight-or-flight response in the body, causing the heart to pump blood more forcefully to the vital organs, thus increasing blood pressure.

On the other hand, dopamine raises blood pressure by modulating electrolyte balance and by regulating various hormones.

In the PhenQ-Wellbutrin combo, two substances will be working to heighten the blood pressure. Therefore you may expect a hypertensive crisis to occur.

On the whole, you should avoid Wellbutrin with compounds that have a dopaminergic or noradrenergic activity (refers to actions initiated by increased levels of dopamine and noradrenaline in the brain).

Taking PhenQ with Wellbutrin Amplifies The Risk Of Side Effects

Wellbutrin may cause side effects like agitation, insomnia, nervousness, appetite loss, headache, dry mouth, and sweating, which is similar to the list of PhenQ side effects.

Therefore, their combined use can have adverse outcomes like excessive appetite suppression.

However, the only difference is that in PhenQ, multiple ingredients are contributing to these side effects instead of just one active compound, as in Wellbutrin.

For instance, the capsimax powder in PhenQ contains hot pepper compounds called capsaicin, which may increase sweating.

Likewise, dry mouth and headache due to PhenQ may occur because of low blood sugar levels or dehydration.

In this case, the nopal and chromium picolinate in PhenQ cause the blood sugar levels to fall.

Whereas caffeine, another ingredient in PhenQ, can contribute to dehydration by causing excessive sweating and increased urination.

PhenQ cta1

What Drugs Should Not Be Taken With Wellbutrin?

Apart from PhenQ, here are some other medicines that you need to avoid with Wellbutrin.

Monoamine Oxidase Inhibitors (Because They Make Blood Pressure Rise)

Parallel use of monoamine oxidase inhibitors (MAOIs) with Wellbutrin may cause dangerously high blood pressure.

Therefore, allow at least two weeks gap between both treatments.

Just so you have an idea, MAOIs are prescribed to patients with depression and Parkinson’s disease.

You may find these drugs being sold under names like Marplan, Nardil, Emsam, or Eldepryl.

Certain Dopaminergic Agents (Because They May Cause Dopamine Toxicity)

As I discussed earlier, abnormally high levels of dopamine in the brain can cause side effects.

Therefore, beware of using Wellbutrin with drugs that influence dopamine release and function.

Such drugs are commonly prescribed for the treatment of Parkinson’s disease, depression, anxiety, ADHD, narcolepsy, obesity, drug addiction, and sexual dysfunction.

Some examples of names that you should look out for are levodopa, amantadine, lisuride, phenethylamine, amphetamine, phenelzine, selegiline, entacapone, and pramipexole.

Drugs That Affect Liver Enzymes (Because This May Alter Wellbutrin’s Concentration)

Like most drugs, Wellbutrin is also metabolized in the liver, which impacts its availability in the body.

However, certain drugs can influence the liver enzyme that mediates this metabolism which either raises or lowers bupropion levels in the body.

Hence, you need to discuss your prescription with a healthcare provider for advice on how you should adjust the dose of Wellbutrin or other drugs when taking them together.

For instance, here are a few drugs that create the need for dose adjustments.

Plavix, Norvir, selective serotonin uptake inhibitors (SSRIs), Beta-blockers, heart medicines, antipsychotics, tricyclic antidepressants, etc.

Medicines That May Cause Seizures (Because Wellbutrin Also Has The Same Risk)

Some medicines, including Wellbutrin, can make it more likely for you to have a seizure.

Therefore, taking them together can amplify this risk to many folds.

Your doctor can guide you better after overviewing your prescription, but for an idea, such medicines are available under brand names like Benadryl, Flexaril, or Clozaril.

What Weight Loss Pill Can I Take With Wellbutrin?

Now that you understand why combining PhenQ with Wellbutrin is not recommended, you might be wondering which weight loss pill will work with it instead.

Fret not because a legal, safe, and FDA-approvedFDA-approved combination is already available to address this concern.

This prescription weight loss drug contains Naltrexone and Bupropion, and it goes by the name Contrave.

You have to use it with a calorie deficit diet and exercise to attain your desired body weight.

What Medications Should Not Be Taken With PhenQ?

Apart from Welbutrin, here are some drug classes that you should not take with PhenQ:

  • Antibiotics, anti-allergens, antihypertensive medicines, blood thinners, pain killers, antidiabetics, and cholesterol medicines.

However, since this is just a summary and there is more to know, like how PhenQ might react to these medicines and what the outcome could be so, check out my detailed blog post about how PhenQ can interact with different medications; if you are interested in knowing the complete details.

Last but not least, the official website does not clearly mention the drugs that you should avoid pairing with PhenQ, so always consult a doctor before taking new pills.

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