Tirzepatide Vs. PhenQ – Is OTC or Prescription Pill Better for Weight Loss?

October 21, 2023 |

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Are you in pursuit of effective weight loss solutions?

In that case, if you’re contemplating the champion between PhenQ and Trizepatide, their weight loss results might help you make the choice.

Considering this, in the SURMOUNT-2 clinical trial, participants who used 15 mg of Trizepatide for one and a half years managed to shed a remarkable 34.4 pounds.

Meanwhile, PhenQ may help you achieve similar or even better results in a much shorter time frame than Trizepatide. To put it in perspective, one PhenQ user reported losing 40 pounds in just 2 months.

Apart from this, PhenQ is a safer and pocket-friendly option than Trizepatide.

Best Choice


Overall rating: 4.9/5
  • Recommended dosage is two pills per day
  • Developed for obese and overweight individuals
  • OTC diet pill – Manufactured in FDA-approved facilities
  • Burns fat, reduces appetite, and preserves lean muscle
  • Exclusively available on the official website.
Best Value


Overall rating: 3.9/5
  • Injection is administered once a week
  • Essentially designed for type 2 diabetics
  • Prescription FDA-approved anti-diabetic
  • Eliminates fat, lowers appetite, & improves glycemic control
  • Can be purchased from online & local pharmacies

What Is PhenQ & How Does It Work?

PhenQ is a natural OTC weight loss pill that you can use in conjunction with a calorie-deficit diet and exercise to achieve your desired weight.

In this regard, PhenQ works in five ways. It melts away the fat, prevents its re-accumulation, increases energy for workouts, suppresses appetite, and improves mood.

3 PhenQ Bottles

It includes ingredients such as caffeine that activate responses that slow down your digestion and promote stomach fullness while simultaneously accelerating the rate of calorie burning.

Similarly, it utilizes L- L-carnitine L-tartrate to preserve muscle mass, which ensures that losing weight gives you a lean instead of a thin figure.

PhenQ Pros

  • Manufactured in GMP and FDA-approved facilities
  • No allergens (gluten, soy, dairy, peanuts, and shellfish)
  • Vegan and vegetarian-friendly
  • Free U.S. delivery 60-day money-back guarantee
  • Cost-effective: a month’s supply costs $69.99.

PhenQ Cons

  • Not for ages below 18 years of age
  • Caution is advised for use by pregnant and lactating women
  • Contains sucrose.

What Is Tirzepatide & How Does It Work?

Trizepatide is an FDA-approved prescription injection that stabilizes blood sugar levels of type 2 diabetics. Nonetheless, doctors have started to prescribe it off-label for weight loss as well.


It is a synthetic peptide consisting of 39 amino acids that act as an agonist of the gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. 

Its attachment to these receptors stimulates the secretion of insulin and adiponectin hormone, which lower blood sugar levels and avert hunger pangs, respectively. These hormones also help lower the body’s fat mass. 

Therefore, Trizepatide does have some similarities with PhenQ’s effect except that it doesn’t increase energy for workouts.

Tirzepatide Pros

  • Effective anti-diabetic drug.
  • Injected once weekly
  • Used for improving glycemic control and for weight reduction.

Tirzepatide Cons

  • Only available upon prescription
  • Awaits FDA approval as a weight loss drug
  • Available in injection form only
  • Recommended for adults only
  • Poses a risk of both acute and chronic side effects like thyroid tumors or kidney issues.
  • Expensive: A single carton (contains 4 pens) of 2.5mg/0.5 ml costs between $1000 – $1500.

Tirzepatide is sold under the brand name Mounjaro, which is only available on prescription. So, no link here, sorry. 🙁

PhenQ Vs. Tirzepatide – Product Comparison

Brand Reputation

Both PhenQ and Trizepatide are products from renowned companies with different visions.

On the one hand, PhenQ was introduced by Wolfsons Brands Ltd., a health and wellness brand that has built a reliable reputation for itself in the past 16 years.

On the other hand, Trizepatide was developed by Eli Lilly, and it is sold under the brand name Mounjaro. Eli Lilly has had a prominent presence in the life sciences industry for the past 147 years. Moreover, it owns the patent for numerous pioneer drugs like insulin. 

Key Ingredients

PhenQ is a multi-ingredient supplement, while Trizepatide is a standalone drug with inherent antidiabetic properties.

Correspondingly, PhenQ uses components such as caffeine and Capsimax that influence your brain in a manner that enhances feelings of fullness and boosts fat oxidation rate. Plus, it employs L-carnitine L- L-tartrate to ensure that you don’t lose your lean muscle mass on your slimming journey.

In comparison, Trizepatide competitively binds to GLP and GIP receptors in the gut such that it triggers pathways that suppress hunger and break down excess body fat.

Common Ingredients

  • None

Unique PhenQ ingredients

  • Caffeine
  • Vitamin (B3, B6, B12)
  • Piperine
  • Capsimax
  • L- carnitine L-Tartrate
  • Nopal 
  • InnoSlim
  • α- Lacy’s Reset

Unique Trizepatide Ingredients

  • Trizepatide

Dosage Regimen

Trizepatide comes in injection form, whereas PhenQ is supplied as pills. Now, your preference will decide which one has the better dosage form.

Doctors usually prescribe a shot of Trizepatide injection once a week, either with or without meals. They may suggest gradually increasing your dose from 2.5 mg to a maximum of 15 mg during treatment.

In contrast, the manufacturers advise taking one PhenQ pill with your breakfast and another with your lunch, making sure not to consume it later than 3 p.m.


PhenQ and Trizepatide belong to brands with distinct motivations – Wolfson Brands Ltd and Eli Lilly, respectively. In a similar vein, they feature discrete compositions and dosage regimes.

Correspondingly, PhenQ is a multi-ingredient weight loss pill, whereas Trizepatide is an injectable anti-diabetic drug.

PhenQ CT

PhenQ or Tirzepatide – Which Is Best For Weight Loss?

PhenQ Gets Rid Of Fat And Prevents It From Coming Back

PhenQ has multiple ingredients to do away with fat. These include caffeine, Capsimax, nopal, L-carnitine L-tartrate, α- LACY’s reset, and InnoSlim. In comparison, Trizepatide induces fat loss by messing with certain hormones.

Intensifies Fat Oxidation

Starting with the PhenQ’s formulation, studies report that caffeine can enhance the breakdown of fat by 10%. 

Likewise, studies document that capsaicin compounds in Capsimax may dissolve the fat by increasing thermogenesis by 8%. Furthermore, a clinical trial found that InnoSlim caused a 29.5% increase in adiponectin levels, which is a hormone that promotes fat oxidation.

In this respect, Trizepatide also increases adiponectin levels by binding to the GLP-1 receptor. Regarding this, a murine experiment reports that Trizepatide led to a 25.7% greater reduction in the fat mass of participants compared to the placebo (33.9% Vs. 8.2%).

Amplifies Reduction In Fat Mass

Apart from that, a clinical trial showed that nopal caused about 11% higher fecal fat excretion in the participants than placebo.

Additionally, scientists observed that compared to placebo, α- LACY’s reset caused a 7.24% reduction in body fat of the participants.

Promotes Utilization of Fat As Energy Substrate

Furthermore, a study found that L- carnitine L- tartrate supplementation caused a 55% increase in muscle glycogen sparing, which was accompanied by an equivalent increase in lipid utilization for energy.

PhenQ May Exert A Stronger Appetite Control

PhenQ and Trizepatide take identical approaches to curb overeating, but you might perceive PhenQ’s appetite suppression as more potent because it pairs two ingredients to intensify it.

As for Trizepatide, it decreases food intake by binding to the GLP-1 receptor, which in turn influences the hypothalamus region of the brain to regulate satiety and reduces gastric emptying.

PhenQ works similarly; it employs the capsaicin compounds in Capsimax to increase the levels of the anorexigenic hormone GLP-1 that exerts control of satiety and hunger.

In addition to this, PhenQ incorporates caffeine, which reinforces the delay in gastric emptying, which may further strengthen the hunger block.

PhenQ Exclusively Helps To Retain Fat-Free Muscle Mass

PhenQ uses components like α-Lacy’s Reset and L-carnitine tartrate to maintain lean muscle, but Trizepatide lacks this property.

Among these, L-carnitine prevents muscle flattening by preserving its glycogen stores and by promoting muscle recovery after exercise. Besides that, a clinical trial reports that α- Lacy’s Reset caused a 3.80% increase in the participant’s muscle mass as compared to placebo.


PhenQ is an all-rounder weight loss supplement. It has a better ability to annihilate fat, kill appetite, and preserve lean muscle than Trizepatide.

PhenQ ingredients essentially optimize the body systems for achieving normal weight. Conversely, Trizepatide messes with the hormones causing a similar impact.

PhenQ CT

PhenQ And Tirzepatide Side Effects – Which Is Safer?

PhenQ Side Effects

PhenQ poses mild side effects like stomach upset, nausea, bloating, or headache.

In this regard, TN shares on Trustpilot that PhenQ made him feel full, but it also caused bloating that lasted throughout the entire month of use.

Tirzepatide Side Effects

Trizepatide has a diverse list of potential side effects. 

For instance, you may notice mild effects like decreased hunger, changes in bowel habits, indigestion, nausea, vomiting, and abdominal pain. 

Apart from that, it may pose a slightly concerning risk of an allergic reaction.

In the worst case, they can even lead to thyroid tumors, pancreatitis, kidney problems, severe gastrointestinal issues, vision changes, and gallbladder problems. 

To be on the safe side, avoid using it if anyone in your family has medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

For instance, a Reddit poll reveals the vast majority of Mounjaro users have faced mild side effects with it. The second majority of users had no complaints. The third largest group of respondents had moderate effects. While only a few suffered from severe complications.

In addition to that, a Reddit user shared that she got side effects from using Mounjaro after extensive use for almost a year. She suffered from severe vomiting, diarrhea, and burping, which ultimately led to extreme dehydration.


PhenQ is safer than Trizepatide. The reason is that the former poses self-limiting side effects while the latter may cause chronic and acute side effects and may negatively impact long-term health.

PhenQ CT

PhenQ Vs. Trizepatide – Which One Is More Affordable?

PhenQ – Where To Buy & Price

You can purchase PhenQ only from the official website.

Here, the discounted price of a single bottle (60 tablets) that lasts a month is $69.99.

For better savings, you may buy the three-month or five-month bundle that will come for $139.99 and $209.99, respectively.

Tirzepatide – Where To Buy & Price

You need a doctor’s prescription to buy Trizepatide.

Once you have it, you may purchase it from most of your nearby pharmacies like Kroger, Costco, Walmart, CVS, or Walgreens. 

And, if you don’t want to head out, then you can also order it online from Amazon Pharmacy.

However, the price of the injection may vary for each brand and at each pharmacy.

To provide you with a rough estimate, according to GoodRx.com, if you want to stay covered for a month, then one carton (4 pens) of 2.5mg/ 0.5 ml Trizepatide injections costs between $1000 to $1500.

Correspondingly, the above-specified carton is available at a retail price of $1228 at Walmart but for $1207 at CVS Pharmacy.


PhenQ costs approximately 17 times less than Trizepatide.

PhenQ CT


What drug is similar to Tirzepatide?

Ozempic has a similar mechanism of action to Trizepatide and belongs to the same drug class, ‘incretin mimetics’. Both of them mimic the GLP-1 hormones to impart blood sugar control.

Still, Trizepatide has a more elaborate action as it additionally targets the GIP receptor. Hence, it may exert stronger effects.

What is an alternative to Tirzepatide injections?

As mentioned on drugs.com, You may use Metformin pills or Ozempic injections as an alternative to Trizepatide for controlling blood sugar levels. 

Is there a Tirzepatide pill?

No, Trizepatide is not available in oral form. It can only be bought in injection dosages of 2.5 mg/0.5 mL, 5 mg/0.5 mL, 7.5 mg/0.5 mL, 10 mg/0.5 mL, 12.5 mg/0.5 mL and 15 mg/0.5 mL.

Which Weight Loss Supplement Is Best?

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